Package | Dosage | Price | Price per Dose | |
---|---|---|---|---|
Dosage: 25mg | ||||
120 pill | 25mg | $108.99 | $0.91 | |
90 pill | 25mg | $85.99 | $0.95 | |
60 pill | 25mg | $58.99 | $0.98 | |
30 pill | 25mg | $30.99 | $1.04 | |
Dosage: 50mg | ||||
270 pill | 50mg | $239.99 | $0.89 | |
240 pill | 50mg | $217.99 | $0.91 | |
120 pill | 50mg | $127.99 | $1.07 | |
90 pill | 50mg | $111.99 | $1.24 | |
60 pill | 50mg | $77.99 | $1.30 | |
30 pill | 50mg | $40.99 | $1.36 |

Azathioprine Description
Overview of Azathioprine
Azathioprine is an immunosuppressive medication commonly used to manage autoimmune conditions and prevent organ transplant rejection. It is classified as an antimetabolite, which works by inhibiting the synthesis of DNA, thereby reducing the proliferation of certain immune cells. This mechanism helps to decrease the abnormal immune response associated with various diseases. Azathioprine has been prescribed for decades and is well-known for its effectiveness in controlling immune-mediated disorders.
Uses and Applications
The primary applications of Azathioprine include treatment of rheumatoid arthritis, inflammatory bowel disease such as Crohn's disease and ulcerative colitis, as well as in organ transplantation to lower the risk of rejection. It may also be employed for autoimmune skin diseases and some types of vasculitis. This versatility makes Azathioprine a valuable drug in the management of many chronic immune conditions. However, its use must be carefully monitored by a healthcare professional to ensure safety and efficacy.
How It Works
Azathioprine is a prodrug that gets converted into 6-mercaptopurine once inside the body. This active metabolite interferes with purine synthesis, which is essential for rapidly dividing cells like lymphocytes. By suppressing the activity of these immune cells, Azathioprine effectively reduces inflammation and immune overactivity. This suppression helps prevent tissue damage in autoimmune diseases and reduces the likelihood of organ rejection after transplantation.
Potential Benefits
Patients taking Azathioprine often experience significant improvement in their symptoms. For autoimmune conditions, this can mean reduced inflammation, less pain, and improved quality of life. In transplant cases, Azathioprine helps sustain graft survival and prevent rejection episodes. Its ability to modulate the immune system makes it a powerful tool for managing complex immune-related health issues. When used correctly, many patients find that it contributes to better disease control with manageable side effects.
Possible Side Effects
Like many immunosuppressive drugs, Azathioprine may cause adverse effects. Common side effects include nausea, vomiting, and decreased appetite. Some patients may develop bone marrow suppression, leading to low blood cell counts, which can increase infection risk and cause fatigue or bleeding tendencies. Liver toxicity is another concern, so liver function tests are often monitored regularly. Allergic reactions, though less common, can manifest as rash, fever, or respiratory symptoms. It is crucial to report any unusual symptoms to a healthcare provider promptly.
Precautions and Considerations
Before starting Azathioprine, healthcare providers typically perform blood tests and assess liver and kidney function. Patients are advised to avoid live vaccines during treatment and to inform their doctor of all other medications they are taking, as drug interactions are possible. Regular blood monitoring is essential to track blood cell counts and liver function. Pregnant or breastfeeding women should discuss potential risks with their healthcare provider, as the medication may affect fetal development or be passed through breast milk. Patients with a history of blood disorders or infections should use Azathioprine with caution.
Conclusion
Azathioprine remains a cornerstone in the management of immune-related diseases and transplantation. Its efficacy in dampening overactive immune responses makes it a valuable medication. Nevertheless, its use requires careful oversight due to possible serious side effects and potential drug interactions. When prescribed and monitored appropriately, Azathioprine can significantly help improve patient outcomes and quality of life in chronic autoimmune conditions and post-transplant care.